This study presents a comprehensive, transient, 3D Computational Fluid Dynamics (CFD) model of a multi-cylinder flat engine's lubrication system, simulated using Simerics-MP+. Engine lubrication system is crucial for reducing friction, cooling, and cleaning engine components. Understanding its performance is essential for optimal engine operation. The model was applied to the lubrication system of a 4-cylinder, reciprocating internal combustion engine. The computational domain includes the positive displacement gear pump, pressure regulation valve, bearings, piston pins, piston cooling jets, oil cooler, oil filter, and other relevant components. Bearing deformation and orbiting due to force imbalance were prescribed in the simulations. A series of simulations were conducted under both fixed and time-dependent gear pump rotation speeds. For fixed speeds, the simulated flow pressure distributions closely matched experimental data. For time-dependent speeds, the predicted pressure buildup